Background Children often develop an asymptomatic form of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), but it is debated if children are at higher risk than adults to be asymptomatic carriers of SARS-CoV-2, especially during the school reopening. The main aim of this study was to investigate the frequency of SARS-CoV-2 asymptomatic carriers in children and adults during the reopening of the schools in Milan, Italy. Methods We conducted a cross-sectional study at the pediatric and adult Emergency Department (ED) of the Ca’ Granda Ospedale Maggiore Policlinico (Milan) between October 1 and 31, 2020, i.e. 3 weeks after the reopening of schools. Patients admitted to the ED short stay observation and without any sign or symptom consistent with a SARS-CoV-2 were eligible. These patients underwent a nasopharyngeal swab specimen for the detection of SARS-CoV-2. The odds ratio and its 95% confidence interval (CI) was calculated to assess the risk of asymptomatically carrying the SARS-CoV-2 infection in children and adults. Results A total of 69 (27 females, median age 8.7 years) children and 251 (107 females, median age 71 years) adults were enrolled. Pediatric and adult subjects tested positive for SARS-CoV-2 with a similar frequency (1/69 [1.4%] vs 4/251 [1.6%]). Children had an odds ratio to be a carrier of 0.91 (CI 0.02– 9.38) compared to adults. Conclusions The frequency of asymptomatic SARS-CoV-2 carriers was similar among children and adults. Considering the emerging diffusion of new SARS-CoV-2 variants, the asymptomatic spread of SARS-CoV-2 infection among children and adults should be monitored.
【초록키워드】 severe acute respiratory syndrome coronavirus 2, SARS-CoV-2, coronavirus, cross-sectional, SARS-COV-2 infection, pediatric, children, Infection, risk, Asymptomatic carrier, Symptom, Italy, severe acute respiratory syndrome Coronavirus, coronavirus 2, variants, emergency department, Spread, Nasopharyngeal swab, Adults, Schools, cross-sectional study, Asymptomatic, asymptomatic form, Patient, Asymptomatic carriers, School, respiratory, Frequency, Emergency, Odds ratio, observation, higher risk, acute respiratory syndrome coronavirus, median age, reopening, Department, positive, carrier, nasopharyngeal swab specimen, females, new SARS-CoV-2, Result, enrolled, tested, develop, conducted, calculated, adult subject, eligible, the SARS-CoV-2, 【제목키워드】 SARS-CoV-2, children, Asymptomatic carrier, Asymptomatic carriers,