Interferons (IFNs) are induced by viruses and are the main regulators of the host antiviral response. They balance tissue tolerance and immune resistance against viral challenges. Like all cells in the human body, neutrophils possess the receptors for IFNs and contribute to antiviral host defense. To combat viruses, neutrophils utilize various mechanisms, such as viral sensing, neutrophil extracellular trap formation, and antigen presentation. These mechanisms have also been linked to tissue damage during viral infection and inflammation. In this review, we presented evidence that a complex cross-regulatory talk between IFNs and neutrophils initiates appropriate antiviral immune responses and regulates them to minimize tissue damage. We also explored recent exciting research elucidating the interactions between IFNs, neutrophils, and severe acute respiratory syndrome-coronavirus-2, as an example of neutrophil and IFN cross-regulatory talk. Dissecting the IFN-neutrophil paradigm is needed for well-balanced antiviral therapeutics and development of novel treatments against many major epidemic or pandemic viral infections, including the ongoing pandemic of the coronavirus disease that emerged in 2019.
【저자키워드】 COVID-19, Neutrophils, type I interferon, antiviral responses, 【초록키워드】 Treatment, coronavirus disease, viruses, Neutrophils, Inflammation, Tolerance, viral infection, coronavirus, pandemic, Antiviral, neutrophil, interferons, viral infections, Severe acute respiratory syndrome, Epidemic, Viral, immune responses, Research, Neutrophil extracellular trap, IFN, antiviral therapeutics, mechanisms, receptors, receptor, Antigen presentation, respiratory, mechanism, severe acute respiratory syndrome-coronavirus-2, IFNs, Evidence, Interaction, host defense, regulate, balance, human body, antiviral immune response, acute respiratory syndrome, tissue, tissue damage, damage, interferons (IFNs), complex, host antiviral response, Defense, TRAP, immune resistance, Host, Cell, virus, example, contribute, Like, initiate, 【제목키워드】 Neutrophils, Type,