Severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2) has infected >235 million people and killed over 4.8 million individuals worldwide. Although vaccines have been developed for prophylactic management, there are no clinically proven antivirals to treat the viral infection. Continuous efforts are being made all over the world to develop effective drugs but these are being delayed by periodic outbreak of mutated SARS-CoV-2 and a lack of knowledge of molecular mechanisms underlying viral pathogenesis and post-infection complications. In this regard, the involvement of Annexin A2 (AnxA2), a lipid-raft related phospholipid-binding protein, in SARS-CoV-2 attachment, internalization, and replication has been discussed. In addition to the evidence from published literature, we have performed in silico docking of viral spike glycoprotein and RNA-dependent RNA polymerase with human AnxA2 to find the molecular interactions. Overall, this review provides the molecular insights into a potential role of AnxA2 in the SARS-CoV-2 pathogenesis and post-infection complications, especially thrombosis, cytokine storm, and insulin resistance.
【저자키워드】 COVID-19, SARS-CoV-2, Cytokine storm, Pathogenesis, thrombosis, Infection, insulin resistance, Annexin A2, 【초록키워드】 viral infection, Vaccine, Cytokine storm, thrombosis, Antiviral, knowledge, viral pathogenesis, spike glycoprotein, cytokine, docking, in silico, Prophylactic, molecular mechanism, effective drugs, Replication, Severe acute respiratory syndrome, Protein, Viral, outbreak, management, insulin resistance, RNA-dependent RNA polymerase, complications, glycoprotein, molecular, respiratory, insulin, SARS-CoV-2 pathogenesis, interactions, Evidence, Post-infection, individual, molecular mechanisms, effort, treat, internalization, viral spike, Annexin, AnxA2, performed, lack, develop, addition, clinically, provide, mutated, Continuous, effective drug, the SARS-CoV-2, 【제목키워드】 Complication, role, insight,