This study aims to measure immunoglobulin G (IgG) and immunoglobulin M (IgM) response after detection of Severe Acute Respiratory Syndrome coronavirus (SARS CoV-2) antigens in coronavirus disease 2019 (COVID-19) patients concerning the severity of symptoms. SARS CoV-2 antigen was confirmed by rapid antigen test, and IgG and IgM were confirmed by VIDAS® SARS-COV-2 IgM and VIDAS® SARS-CoV-2 IgG automated qualitative assays used to rapidly detect antibodies 20–30 days after detection. The serological assay for detecting SARS-CoV-2 IgM and IgG antibodies shows a positive correlation for all patients detected with SARS-CoV-2 antigen with sensitivity 100% with differences in antibodies levels between patients regarding age and significantly related clinical symptoms with p-value 0.013 <0.05. The appearance of clinical symptoms was not significantly related to IgG levels at a p-value of 0.4 >0.05. However, the appearance of clinical symptoms was significantly related to IgM levels at a p-value of 0.002 <0.05. Antigen-dependent rapid tests can be used to detect SARS-CoV-2 in an early stage of infection with high sensitivity and specificity. Moreover, this study shows the age groups 21–30 and 31–40 have a better response to SARS-CoV-2 infection.
【저자키워드】 SARS CoV-2, IgG, IgM, Clinical symptoms, antigen rapid test, 【초록키워드】 COVID-19, SARS CoV-2, coronavirus disease, SARS-CoV-2, Coronavirus disease 2019, coronavirus, Clinical symptoms, antibody, SARS-COV-2 infection, Infection, severe acute respiratory syndrome Coronavirus, Antigen, sensitivity, Immunoglobulin G, IgG antibody, Serological assay, Rapid test, Immunoglobulin, Sensitivity and specificity, IgG antibodies, Patient, age, automated, SARS-CoV-2 antigen, respiratory, group, early stage, SARS-CoV-2 IgG, SARS-CoV-2 IgM, Rapid tests, immunoglobulin M, IgG and IgM, P-value, acute respiratory syndrome coronavirus, clinical symptom, SARS CoV, positive correlation, appearance, IgG levels, severity of symptoms, respiratory syndrome coronavirus, detect, significantly, can be used, concerning, IgG level, 【제목키워드】 Antigen, COVID-19 patient, IgG and IgM, severity of symptom,