The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic posed a serious public health concern and started a race against time for researchers to discover an effective and safe therapy for coronavirus disease 2019 (COVID-19), the disease caused by SARS-CoV-2. This review aims to describe the history, efficacy, and safety of five potential therapeutics for COVID-19, remdesivir, favipiravir, hydroxychloroquine, tocilizumab, and convalescent plasma. A literature review was conducted through October 2020 to identify published studies evaluating the efficacy and safety of these five potential therapeutics. Clinical improvement was used to assess the efficacy, while reported withdrawals from study participation and adverse events were used to evaluate the safety. In total, 95 clinical studies (6 interventional and 89 observational studies) were obtained, of which 42 were included in this review. The evaluation of the efficacy and safety profiles is challenging due to the limitations of the clinical studies on one hand, and the limited number of randomized controlled trials (RCTs) on the other. Moreover, there was insufficient evidence to support repurposing remdesivir, favipiravir, and tocilizumab for COVID-19.
【저자키워드】 COVID-19, Efficacy, Safety, Therapeutics, 【초록키워드】 Randomized controlled trial, coronavirus disease, convalescent plasma, public health, SARS-CoV-2, Coronavirus disease 2019, coronavirus, pandemic, therapy, Randomized controlled trials, Hydroxychloroquine, Tocilizumab, Remdesivir, Favipiravir, Withdrawal, severe acute respiratory syndrome Coronavirus, observational studies, adverse events, clinical, adverse event, Clinical improvement, Clinical studies, Efficacy and safety, respiratory, RCTs, clinical study, Evidence, Safe, Support, literature review, acute respiratory syndrome, acute respiratory syndrome coronavirus, acute respiratory syndrome coronavirus 2, profile, limitation, study participation, researcher, FIVE, effective, identify, was used, evaluate, caused, reported, the disease, conducted, were used, 【제목키워드】 life, history, narrative, Potential,