Background: The aim of our study was to examine the performance of two assays in detecting SARS-CoV-2 antibodies. Methods: A total of 127 COVID-19 disease contacts from the Infectious Diseases Department were included. Two serological tests were used: SARS-CoV-2 IgG CMIA on the Alinity system (Abbott) and LIAISON ® SARS-CoV-2 S1/S2 IgG CLIA (DiaSorin). Results: The assays exhibited a 96.85% (123/127 patients) test result agreement. In two cases, the positive results obtained by SARS-CoV-2 IgG CMIA on the Alinity system (Abbott) were negative based on the LIAISON ® SARS-CoV-2 S1/S2 IgG CLIA (DiaSorin) test, and in two cases, negative results from the LIAISON ® SARS-CoV-2 S1/S2 IgG CLIA (DiaSorin) test were positive with the SARS-CoV-2 IgG CMIA on the Alinity system (Abbott). Conclusions: Based on the results of our study, we conclude that in population medicine, the assessments of anti-SARS-CoV-2 antibodies after exposure to SARS-CoV-2 virus based on spike protein or nucleocapsid protein show comparable effectiveness.
【저자키워드】 SARS-CoV-2, serology, Spike protein, nucleocapsid protein, chemiluminescent immunoassay, 【초록키워드】 serological test, CLIA, IgG, SARS-CoV-2 virus, Infectious disease, Spike protein, nucleocapsid protein, COVID-19 disease, anti-SARS-CoV-2 antibodies, SARS-CoV-2 antibodies, Serological tests, anti-SARS-CoV-2 antibody, CMIA, Effectiveness, assessment, patients, SARS-CoV-2 IgG, Contact, LIAISON, Abbott, exposure to, test result, (Abbott, population medicine, (Abbott), assessments, positive result, DiaSorin, S1/S2, Department, positive, exhibited, comparable, the SARS-CoV-2,