Influenza A virus (IAV) PB1-F2 protein has been linked to viral virulence. Strains of the H3N2 subtype historically express full-length PB1-F2 proteins but during the 2010–2011 influenza seasons, nearly half of the circulating H3N2 IAVs encoded truncated PB1-F2 protein. Using a panel of reverse engineered H3N2 IAVs differing only in the origin of the PB1 gene segment, we found that only the virus encoding the avian-derived 1968 PB1 gene matching the human pandemic strain enhanced cellular infiltrate into the alveolar spaces of infected mice. We linked this phenomenon to expression of full-length PB1-F2 protein encompassing critical “inflammatory” residues. Electronic supplementary material The online version of this article (doi:10.1186/s12985-017-0827-0) contains supplementary material, which is available to authorized users.
【저자키워드】 Inflammation, pandemic, influenza A virus, Respiratory disease, pathogenicity, virulence, seasonal, PB1-F2,