Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) caused the global pandemic of coronavirus disease 2019 (COVID-19). Rapid identification and isolation of infectious patients are critical methods to block COVID-19 transmission. Antigen tests can contribute to prompt identification of infectious individuals. This meta-analysis aims to evaluate the diagnostic accuracy of antigen tests for SARS-CoV-2. We conducted a literature search in PubMed, Embase, the Cochrane Library, and Biomed Central databases. Studies evaluating the diagnostic accuracy of antigen tests for SARS-CoV-2 in community participants were included. Only English-language articles were reviewed. We included eligible studies that provided available data to construct a 2 × 2 table on a per-patient basis. Overall sensitivity and specificity for antigen tests were generated using a bivariate random-effects model. Eighteen studies with 34,865 participants were retrieved. The meta-analysis for SARS-CoV-2 antigen tests generated a pooled sensitivity of 0.82 and a pooled specificity of 1.00. A subgroup analysis of ten studies that reported outcomes for 5629 symptomatic participants generated a pooled sensitivity of 0.87 and a pooled specificity of 1.00. Antigen tests might have higher sensitivity in detecting SARS-CoV-2 in symptomatic patients in the community and may be an effective tool to identify patients to be quarantined to prevent further SARS-CoV-2 transmission.
【저자키워드】 COVID-19, Meta-analysis, SARS-CoV-2, Sensitivity and specificity, antigen test, 【초록키워드】 coronavirus disease, Meta-analysis, Coronavirus disease 2019, diagnostic, severe acute respiratory syndrome coronavirus-2, outcome, Antigen, global pandemic, Severe acute respiratory syndrome, sensitivity, specificity, Diagnostic accuracy, SARS-CoV-2 transmission, Symptomatic patients, Accuracy, Patient, Isolation, Rapid, Community, antigen tests, SARS-CoV-2 antigen, infectious, respiratory, Critical, COVID-19 transmission, acute respiratory syndrome, available data, Cochrane Library, participant, subgroup analysis, random-effects model, article, Prevent, effective, identify, evaluate, caused, reported, conducted, provided, contribute, individuals, eligible, retrieved, symptomatic participant, symptomatic patient, 【제목키워드】 review, Test,