Infection with SARS-CoV-2, the causative agent of COVID-19, causes mild to moderate disease in most patients but carries a risk of morbidity and mortality. Seriously affected individuals manifest disorders of hemostasis and a cytokine storm, but it is not understood how these manifestations of severe COVID-19 are linked. Here, we showed that the SARS-CoV-2 spike protein engaged the CD42b receptor to activate platelets via 2 distinct signaling pathways and promoted platelet-monocyte communication through the engagement of P selectin/PGSL-1 and CD40L/CD40, which led to proinflammatory cytokine production by monocytes. These results explain why hypercoagulation, monocyte activation, and a cytokine storm are correlated in patients severely affected by COVID-19 and suggest a potential target for therapeutic intervention.
【저자키워드】 COVID-19, Monocytes, Inflammation, Platelets, 【초록키워드】 Monocytes, SARS-CoV-2, Cytokine storm, severe COVID-19, risk, Platelets, CD40L, cytokine, Spike protein, Engagement, monocyte, Hemostasis, SARS-CoV-2 spike protein, morbidity, Patient, Platelet, Mild, morbidity and mortality, signaling pathway, receptor, Hypercoagulation, manifestation, mild to moderate, causative agent, Proinflammatory cytokine, disorders, mild to moderate disease, moderate disease, Monocyte activation, Most patients, individual, therapeutic intervention, CD40, disorder, affected, correlated, cause, activate, explain, promoted, the SARS-CoV-2, 【제목키워드】 Platelets, Activation, inflammatory monocyte,