Background Cardiac evaluations, including cardiovascular magnetic resonance (CMR) imaging and biomarker results, are needed in children during mid-term recovery after infection with SARS-CoV-2. The incidence of CMR abnormalities 1–3 months after recovery is over 50% in older adults and has ranged between 1 and 15% in college athletes. Abnormal cardiac biomarkers are common in adults, even during recovery. Methods We performed CMR imaging in a prospectively-recruited pediatric cohort recovered from COVID-19 and multisystem inflammatory syndrome in children (MIS-C). We obtained CMR data and serum biomarkers. We compared these results to age-matched control patients, imaged prior to the SARS-CoV-2 pandemic. Results CMR was performed in 17 children (13.9 years, all ≤ 18 years) and 29 age-matched control patients without SARS-CoV-2 infection. Cases were recruited with symptomatic COVID-19 (11/17, 65%) or MIS-C (6/17, 35%) and studied an average of 2 months after diagnosis. All COVID-19 patients had been symptomatic with fever (73%), vomiting/diarrhea (64%), or breathing difficulty (55%) during infection. Left ventricular and right ventricular ejection fractions were indistinguishable between cases and controls (p = 0.66 and 0.70, respectively). Mean native global T1, global T2 values and segmental T2 maximum values were also not statistically different from control patients (p ≥ 0.06 for each). NT-proBNP and troponin levels were normal in all children. Conclusions Children prospectively recruited following SARS-CoV-2 infection had normal CMR and cardiac biomarker evaluations during mid-term recovery. Trial Registration Not applicable.
【저자키워드】 COVID-19, SARS-CoV-2, pediatric, MIS-C, Cardiac magnetic resonance imaging, 【초록키워드】 pandemic, Biomarker, Older adults, SARS-COV-2 infection, SARS-CoV-2 pandemic, children, Infection, Diagnosis, troponin, diarrhea, MIS-C, Registration, Adults, symptomatic, Fever, Patient, Control, incidence, serum biomarkers, NT-proBNP, patients, cardiac, symptomatic COVID-19, Inflammatory, COVID-19 patient, not applicable, ventricular ejection, Older, Ejection fraction, Trial registration, average, control patients, syndrome, troponin levels, vomiting, abnormality, left, pediatric cohort, breathing difficulty, Result, performed, recruited, was performed, ranged, statistically, age-matched control, control patient, infection with SARS-CoV-2, the SARS-CoV-2, troponin level, ventricular, 【제목키워드】 magnetic resonance imaging, children, Prospective Study, cardiovascular, symptomatic,