Circadian rhythms are evolutionarily conserved anticipatory systems that allow the host to prepare and respond to threats in its environment. This article summarizes a European Biological Rhythms Society (EBRS) workshop held in July 2020 to review current knowledge of the interplay between the circadian clock and viral infections to inform therapeutic strategies against SARS-CoV-2 and COVID-19. A large body of work supports the role of the circadian clock in regulating various aspects of viral replication, host responses, and associated pathogenesis. We review the evidence describing the multifaceted role of the circadian clock, spanning host susceptibility, antiviral mechanisms, and host resilience. Finally, we define the most pressing research questions and how our knowledge of chronobiology can inform key translational research priorities.
【저자키워드】 COVID-19, viruses, SARS-CoV-2, pandemic, Immunity, circadian rhythms, chronotherapy, 【초록키워드】 Resilience, viral infection, Pathogenesis, Antiviral, knowledge, threat, viral infections, Viral, viral replication, Research, Therapeutic strategies, mechanisms, circadian rhythms, therapeutic strategy, Evidence, host susceptibility, circadian rhythm, host responses, Biological, Biological Rhythms, Support, Society, Threats, CLOCK, Research question, chronobiology, circadian clock, Host, European, rhythm, conserved, respond, translational, 【제목키워드】 lesson,