Abstract From the earliest days of the coronavirus disease 2019 (COVID-19) pandemic, there have been reports of significant neurological and psychological symptoms following Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection. This narrative review is designed to examine the potential psychoneuroendocrine pathogenic mechanisms by which SARS-CoV-2 elicits psychiatric sequelae as well as to posit potential pharmacologic strategies to address and reverse these pathologies. Following a brief overview of neurological and psychological sequelae from previous viral pandemics, we address mechanisms by which SARS-CoV-2 could enter or otherwise elicit changes in the CNS. We then examine the hypothesis that COVID-19–induced psychiatric disorders result from challenges to the neuroendocrine system, in particular the hypothalamic-pituitary-adrenal stress axis and monoamine synthesis, physiological mechanisms that are only further enhanced by the pandemic-induced social environment of fear, isolation, and socioeconomic pressure. Finally, we evaluate several FDA-approved therapeutics in the context of COVID-19–induced psychoneuroendocrine disorders.
【저자키워드】 COVID-19, Therapeutic strategies, Neuroimmunology, neuropsychiatric disorders, neuroendocrine, 【초록키워드】 coronavirus disease, severe acute respiratory syndrome coronavirus 2, SARS-CoV-2, Coronavirus disease 2019, coronavirus, pandemic, Stress, Infection, coronavirus 2, Severe acute respiratory syndrome, Viral, Isolation, Pandemics, Psychiatric disorders, Psychological, respiratory, Pathologies, CNS, pathogenic mechanism, mechanism, Hypothesis, neurological, psychiatric disorder, psychological symptoms, Psychiatric, acute respiratory syndrome, disorders, physiological mechanism, social environment, psychological symptom, evaluate, changes in, elicit, 【제목키워드】 SARS-CoV-2, review, Strategy,