The mortality rate of critically ill patients with acute respiratory distress syndrome (ARDS) is 30.9% to 46.1%. The emergence of the coronavirus disease 2019 (Covid-19) has become a global issue with raising dire concerns. Patients with severe Covid-19 may progress toward ARDS. Mesenchymal stem cells (MSCs) can be derived from bone marrow, umbilical cord, adipose tissue and so on. The easy accessibility and low immunogenicity enable MSCs for allogeneic administration, and thus they were widely used in animal and clinical studies. Accumulating evidence suggests that mesenchymal stem cell infusion can ameliorate ARDS. However, the underlying mechanisms of MSCs need to be discussed. Recent studies showed MSCs can modulate immune/inflammatory cells, attenuate endoplasmic reticulum stress, and inhibit pulmonary fibrosis. The paracrine cytokines and exosomes may account for these beneficial effects. In this review, we summarize the therapeutic mechanisms of MSCs in ARDS, analyzed the most recent animal experiments and Covid-19 clinical trial results, discussed the adverse effects and prospects in the recent studies, and highlight the potential roles of MSC therapy for Covid-19 patients with ARDS.
【저자키워드】 COVID-19, acute respiratory distress syndrome, Mesenchymal stem cells, breath, 【초록키워드】 coronavirus disease, Exosome, Coronavirus disease 2019, ARDS, clinical trial, Cytokines, severe COVID-19, Stress, acute respiratory distress syndrome, Umbilical cord, pulmonary fibrosis, fibrosis, Mesenchymal stem cells, MSCs, Exosomes, cytokine, Bone marrow, Endoplasmic reticulum, adverse effects, Critically ill, cells, animal experiments, therapeutic, Clinical studies, Allogeneic, experiment, mortality rate, mesenchymal stem cell, mechanism, critically ill patients, COVID-19 patients, Adipose tissue, acute respiratory distress, Evidence, administration, MSC, stem cell, respiratory distress, inflammatory cells, Critically ill patient, MSC therapy, adverse effect, tissue, syndrome, cell infusion, adipose, Effects, recent, highlight, analyzed, inhibit, modulate, attenuate, paracrine, patients with ARDS, raising, umbilical, 【제목키워드】 Treatment, Mesenchymal stem cells, mechanism, acute respiratory distress, syndrome,