Background This study aimed to assess tendency of oxidative stress in COVID-19 patients depending on severity. Methods The study was conducted with 80 post-COVID-19 disease patients and 40 acutely ill patients. Content of selenium in blood plasma was detected by a fluorimetric method with di-amino-naphthalene using acidic hydrolysis. Selenoprotein P, malondialdehyde and 4-hydroxynonenal and their metabolite adducts were evaluated by spectrophotometric methods using commercial assay kits. Results Obtained results showed that selenium content in blood for post-COVID-19 disease patients was of a similar lower norm for Latvian inhabitants. Selenium and seleno-protein P contents for acute patients were significantly decreased compared with post-COVID-19 disease patients. Conclusion In conclusion, COVID-19 involves induction of antioxidant systems—in case of severe disease, patients have significantly low concentration of selenium, seleno-protein P and higher level of oxidative stress, which, in turn, confirms the more intense formation of free radicals in the body.
【저자키워드】 COVID-19, oxidative stress, Selenium, Free radicals, Selenoprotein P, 【초록키워드】 severity, oxidative stress, antioxidant, COVID-19 disease, Patient, Selenium, Free radicals, Selenoprotein P, disease, patients, metabolite, COVID-19 patients, Blood, blood plasma, Concentration, severe disease, COVID-19 patient, free radical, malondialdehyde, Acidic, content, tendency, selenoprotein, acutely ill patients, 4-hydroxynonenal, hydrolysis, Result, significantly, evaluated, conducted, turn, 【제목키워드】 Selenium, SARS-CoV-2 patient,