Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel type b coronavirus responsible for the COVID-19 pandemic. With over 224 million confirmed infections with this virus and more than 4.6 million people dead because of it, it is critically important to define the immunological processes occurring in the human response to this virus and pathogenetic mechanisms of its deadly manifestation. This perspective focuses on the contribution of the recently discovered interaction of SARS-CoV-2 Spike protein with neuropilin 1 (NRP1) receptor, NRP1 as a virus entry receptor for SARS-CoV-2, its role in different physiologic and pathologic conditions, and the potential to target the Spike–NRP1 interaction to combat virus infectivity and severe disease manifestations.
【저자키워드】 Comorbidities, COVID-19, Coronavirus disease 2019, SARS-CoV-2, Severe acute respiratory syndrome coronavirus 2, Spike protein, Host immune response, ACE2, angiotensin converting enzyme 2, NRP-1, neuropilin-1, Molecular structures, Immunotargets and strategies, CendR C-end rule, RBD, receptor-biding domain, 【초록키워드】 severe acute respiratory syndrome coronavirus 2, SARS-CoV-2, coronavirus, spike, COVID-19 pandemic, Infection, severe acute respiratory syndrome Coronavirus, virus, Spike protein, Protein, SARS-CoV-2 spike protein, virus entry, NRP1, receptor, respiratory, mechanism, Interaction, acute respiratory syndrome, acute respiratory syndrome coronavirus, Perspective, severe disease manifestations, virus infectivity, dead, immunological, responsible, pathologic, to define, conditions, 【제목키워드】 SARS-COV-2 infection, approach,