Abstract PARP14 and PARP9 play a key role in macrophage immune regulation. SARS‐CoV‐2 is an emerging viral disease that triggers hyper‐inflammation known as a cytokine storm. In this study, using in silico tools, we hypothesize about the immunological phenomena of molecular mimicry between SARS‐CoV‐2 Nsp3 and the human PARP14 and PARP9. The results showed an epitope of SARS‐CoV‐2 Nsp3 protein that contains consensus sequences for both human PARP14 and PARP9 that are antigens for MHC Classes 1 and 2, which can potentially induce an immune response against human PARP14 and PARP9; while its depletion causes a hyper‐inflammatory state in SARS‐CoV‐2 patients. Highlights Molecular mimicry could produce an inflammatory state in SARS‐CoV‐2 patients. Human PARP14 and PARP9 are the proteins involves in this phenomena.
【저자키워드】 Macrophage, Cytokine storm, SARS‐CoV‐2, molecular mimicry, 【초록키워드】 Macrophage, Cytokine storm, immune response, Human, immune regulation, cytokine, in silico, Antigen, SARS‐CoV‐2, Protein, antigens, viral disease, molecular, molecular mimicry, epitope, patients, MHC, consensus sequence, inflammatory state, Trigger, triggers, consensus sequences, PARP14, PARP9, immunological, induce, cause, 【제목키워드】 cytokine, molecular, molecular mimicry, approach, explain, Can, the cytokine storm,