To evaluate the pathophysiology of autoimmune hepatitis (AIH) following acute hepatitis A (AHA) in immunologic aspects, we performed multi-color flow cytometry with peripheral blood mononuclear cells of a patient who underwent liver transplantation due to AIH-induced liver failure. Unlike general AHA patients, the proportion of tumor necrosis factor-α-producing Treg cells remained high for 6 months after diagnosis of AHA until she underwent a liver transplantation. The conversion of Treg cells into mediators of inflammation may have played a role in the autoimmune pathogenesis following AHA.
All Keywords
【저자키워드】 regulatory T cells, Autoimmune hepatitis, Acute hepatitis A, inflammatory conversion of Treg cells,
【저자키워드】 regulatory T cells, Autoimmune hepatitis, Acute hepatitis A, inflammatory conversion of Treg cells,