High-dose of IVIG show immunomodulatory properties that may be useful for controlling the hyperinflammatory status observed in COVID-19 patients. The use of high-dose of intravenous immunoglobulins (IVIGs) as immunomodulators for the treatment of COVID-19–affected individuals has shown promising results. IVIG reduced inflammation in these patients, who progressively restored respiratory function. However, little is known about how they may modulate immune responses in COVID-19 individuals. Here, we have analyzed the levels of 41 inflammatory biomarkers in plasma samples obtained at day 0 (pretreatment initiation), 3, 7, and 14 from five hospitalized COVID-19 patients treated with a 5-d course of 400 mg/kg/d of IVIG. The plasmatic levels of several cytokines (Tumor Necrosis Factor, IL-10, IL-5, and IL-7), chemokines (macrophage inflammatory protein-1α), growth/tissue repairing factors (hepatic growth factor), complement activation (C5a), and intestinal damage such as Fatty acid–binding protein 2 and LPS-binding protein showed a progressive decreasing trend during the next 2 wk after treatment initiation. This trend was not observed in IVIG-untreated COVID-19 patients. Thus, the administration of high-dose IVIG to hospitalized COVID-19 patients may improve their clinical evolution by modulating their hyperinflammatory and immunosuppressive status.
【초록키워드】 COVID-19, Treatment, Inflammation, Macrophage, Tumor, Intravenous immunoglobulin, immune response, Cytokines, Respiratory function, immunoglobulins, complement, cytokine, chemokines, chemokine, IVIG, C5a, Complement activation, immunomodulator, Protein, immunomodulators, tumor necrosis factor, immune responses, IL-10, patients, Fatty acid, COVID-19 patients, IL-7, inflammatory biomarkers, hospitalized COVID-19 patient, Inflammatory biomarker, administration, Inflammatory, immunosuppressive, tumor necrosis, High-dose, Activation, Factor, individual, plasma samples, high-dose IVIg, treatment initiation, clinical evolution, immunomodulatory properties, IL-5, hepatic growth factor, hyperinflammatory status, Hyperinflammatory, FIVE, intestinal, plasma sample, IMPROVE, Course, shown, analyzed, reduced, treated, modulate, individuals, restored, immunomodulatory property, modulating, 【제목키워드】 Inflammation, Intravenous immunoglobulin, COVID-19 patient, modulate,