Abstract Background The lack of knowledge about the specific preventive measures and limited scientific information on severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) led to an excruciating onset and progression of coronavirus disease 2019 (COVID‐19). Swift development of various successful vaccines around the globe is striving to contain the exponential surges of COVID‐19 cases. However, the ongoing struggle to vaccinate the global population and alarming spread of highly transmissible variants may thwart global initiatives to contain SARS‐CoV‐2 as observed by less robust protective immunity. Methods In this perspective, we propose a thought‐provoking, two‐pronged strategy involving RNA interference approach to degrade essential SARS‐CoV‐2 ORFs required for replication and entry in conjunction with a complement inhibitor (compstatin) to stymie the detrimental proinflammatory cytokine storm that exacerbate disease progression and severity. Results We provide supporting evidence suggesting that concurrent targeting of viral and host components will be a superior strategy to effectively suppress viral spread and clinical manifestations of COVID‐19. Conclusion SARS‐CoV‐2 specific RNAi in conjunction with systemic delivery of compstatin will be an effective two‐pronged strategy to combat local and systemic immune responses in both symptomatic and asymptomatic COVID‐19 patients. (1). Multiplex RNA interference (RNAi) can target SARS‐CoV‐2 essential transcripts and its emerging variants. (2). Complement C3a inhibitor compstatin can curtail the cytokine storm in COVID‐19 patients. (3). A novel RNAi and compstatin approach will contain virus and mitigate its downstream perils.
【저자키워드】 complement, infections, gene regulation processes, molecules, viral/retroviral, 【초록키워드】 coronavirus disease, Coronavirus disease 2019, Vaccine, Cytokine storm, coronavirus, knowledge, severity, Local, cytokine, progression, severe acute respiratory syndrome Coronavirus, viral spread, virus, variants, COVID‐19, SARS‐CoV‐2, Replication, clinical manifestations, Spread, Disease progression, Viral, protective immunity, immune responses, RNA interference, preventive measures, respiratory, Complement inhibitor, inhibitor, information, Evidence, RNAi, detrimental, systemic immune response, preventive measure, clinical manifestation, systemic immune responses, Proinflammatory cytokine, acute respiratory syndrome, acute respiratory syndrome coronavirus, acute respiratory syndrome coronavirus 2, COVID‐19 patients, Perspective, conjunction, component, downstream, disease progression and severity, vaccinate, transcript, Host, mitigate, approach, effective, robust, Result, lack, globe, required, ORF, less, suppress, exacerbate, C3a, curtail, degrade, symptomatic and asymptomatic, the cytokine storm, transmissible variant, 【제목키워드】 Treatment, COVID‐19, SARS‐CoV‐2, Host,