To date very few promising leads from natural products (NP) secondary metabolites with antiviral and immunomodulatory properties have been identified for promising/potential intervention for COVID-19. Using in-silico docking studies and genome based various molecular targets, and their in vitro anti-SARS CoV-2 activities against whole cell and/or selected protein targets, we select a few compounds of interest, which can be used as potential leads to counteract effects of uncontrolled innate immune responses, in particular those related to the cytokine storm. A critical factor for prevention and treatment of SARS-CoV-2 infection relates to factors independent of viral infection or host response. They include population-related variables such as concurrent comorbidities and genetic factors critically relevant to COVID-19 health disparities. We discuss population risk factors related to SARS-CoV-2. In addition, we focus on virulence related to glucose-6-phosphate dehydrogenase deficiency (G6PDd), the most common human enzymopathy. Review of data on the response of individuals and communities with high prevalence of G6PDd to NP, prompts us to propose the rationale for a population-specific management approach to rationalize design of therapeutic interventions of SARS-CoV-2 infection, based on use of NP. This strategy may lead to personalized approaches and improve disease-related outcomes.
【저자키워드】 COVID-19, SARS-CoV-2, Cytokine storm, Risk factors, G6PD, Disparities, natural product, in-silico docking, life style variables, 【초록키워드】 Treatment, review, viral infection, Cytokine storm, Antiviral, SARS-COV-2 infection, Genome, Genetic, glucose-6-phosphate dehydrogenase, Comorbidity, Intervention, cytokine, host response, in vitro, risk factor, activity, Prevalence, outcomes, Health, Viral, immune responses, management, Community, targets, molecular, in-silico, virulence, Critical, Glucose, docking study, secondary metabolites, leads, lead, genetic factors, independent of, focus, glucose-6-phosphate dehydrogenase deficiency, Secondary Metabolite, deficiency, Factor, individual, Compound, rationale, Glucose-6-phosphate, therapeutic interventions, therapeutic intervention, protein targets, innate immune responses, variable, enzymopathy, Effect, approach, Cell, independent, IMPROVE, selected, include, addition, can be used, immunomodulatory property, the cytokine storm, 【제목키워드】 survey, natural,