A novel series of 1-aryl- N -[4-phenyl-5-(arylazo)thiazol-2-yl)methanimines has been synthesized via the condensation of 2-amino-4-phenyl-5-arylazothiazole with various aromatic aldehydes. The synthesized imines were characterized by spectroscopic techniques, namely 1 H and 13 C-NMR, FTIR, MS, and Elemental Analysis. A molecular comparative docking study for 3a–f was calculated, with reference to two approved drugs, Molnupiravir and Remdesivir, using 7BQY (M pro ; PDB code 7BQY; resolution: 1.7 A°) under identical conditions. The binding scores against 7BQY were in the range of −7.7 to −8.7 kcal/mol for 3a–f . The high scores of the compounds indicated an enhanced binding affinity of the molecules to the receptor. This is due to the hydrophobic interactions and multi-hydrogen bonds between 3a–f ligands and the receptor’s active amino acid residues. The main aim of using in silco molecular docking was to rank 3a–f with respect to the approved drugs, Molnupiravir and Remdesivir, using free energy methods as greener pastures. A further interesting comparison presented the laydown of the ligands before and after molecular docking. These results and other supporting statistical analyses suggested that ligands 3a–f deserve further investigation in the context of potential therapeutic agents for COVID-19. Free-cost, PASS, SwissADME, and Way2drug were used in this research paper to determine the possible biological activities and cytotoxicity of 3a–f .
【저자키워드】 COVID-19, molnupiravir, Remdesivir, imines-tethered thiazoles, synthesis, in silico molecular docking, greener pastures, 【초록키워드】 molnupiravir, molecular docking, Remdesivir, cytotoxicity, binding affinity, approved drugs, free energy, Research, therapeutic agents, receptor, molecular, molecules, Amino acid, docking study, Ligand, statistical analysis, potential therapeutic agents, ligands, Compound, M pro, amino acid residues, hydrophobic, hydrophobic interactions, condensation, biological activity, Pass, binding scores, aryl, phenyl, PDB, indicated, characterized, calculated, were used, determine, suggested, potential therapeutic agent, conditions, binding score, Elemental, hydrophobic interaction, 【제목키워드】 drug, Biological, candidate, Potential, Pasture,