Data obtained from several intensive care units around the world have provided substantial evidence of the strong association between impairment of the renal function and in-hospital deaths of critically ill COVID-19 patients, especially those with comorbidities and requiring renal replacement therapy (RRT). Acute kidney injury (AKI) is a common renal disorder of various etiologies characterized by a sudden and sustained decrease of renal function. Studies have shown that 5–46% of COVID-19 patients develop AKI during hospital stay, and the mortality of those patients may reach up to 100% depending on various factors, such as organ failures and RRT requirement. Catechins are natural products that have multiple pharmacological activities, including anti-coronavirus and reno-protective activities against kidney injury induced by nephrotoxic agents, obstructive nephropathies and AKI accompanying metabolic and cardiovascular disorders. Therefore, in this review, we discuss the anti-SARS-CoV-2 and reno-protective effects of catechins from a mechanistic perspective. We believe that catechins may serve as promising therapeutics in COVID-19-associated AKI due to their well-recognized anti-SARS-CoV-2, and antioxidant and anti-inflammatory properties that mediate their reno-protective activities.
【저자키워드】 SARS-CoV-2, coronavirus, natural products, flavonoids, medicinal plant, renal disease, nephrotoxicity, reno-protective effect, green tea, epigallocatechin-3-gallate (EGCG), 【초록키워드】 Mortality, Therapeutics, Comorbidities, intensive care unit, Acute kidney injury, anti-SARS-CoV-2, antioxidant, renal function, Kidney injury, activity, AKI, Critically ill, Patient, Cardiovascular disorders, Factors, etiology, catechin, COVID-19 patients, association, renal replacement therapy, Evidence, COVID-19 patient, Organ failure, critically ill COVID-19 patients, Hospital stay, evidence of, replacement therapy, In-hospital death, RRT, renal disorder, Perspective, activities, anti-inflammatory properties, disorder, renal, impairment, pharmacological, nephrotoxic, organ failures, Effect, decrease, shown, develop, provided, characterized, sustained, anti-inflammatory property, obstructive nephropathy, those with comorbidity,