Vitamin D has many effects on cells in the immune system. Many studies have linked low vitamin D status with severity of COVID-19. Genetic variants involved in vitamin D metabolism have been implicated as potential risk factors for severe COVID-19 outcomes. This study investigated how genetic variations in humans affected the clinical presentation of COVID-19. In total, 646 patients with SARS-CoV-2 infection were divided into two groups: noncritical COVID-19 ( n = 453; 70.12%) and a critical group ( n = 193; 29.87%). Genotype data on the GC, NADSYN1, VDR, and CYP2R1 genes along with data on serum 25-hydroxyvitamin D levels were compiled in patients admitted to a major hospital in the United Arab Emirates between April 2020 and January 2021. We identified 12 single-nucleotide polymorphisms associated with the critical COVID-19 condition: rs59241277, rs113574864, rs182901986, rs60349934, and rs113876500; rs4944076, rs4944997, rs4944998, rs4944979, and rs10898210; and rs11574018 and rs11574024. We report significant associations between genetic determinants of vitamin D metabolism and COVID-19 severity in the UAE population. Further research needed to clarify the mechanism of action against viral infection in vitamin D deficiency. These variants could be used with vaccination to manage the spread of SARS-CoV-2 and could be particularly valuable in populations in which vitamin D deficiency is common.
【저자키워드】 COVID-19, Vitamin D, polymorphism, metabolism, UAE, genotypes, 【초록키워드】 SARS-CoV-2, viral infection, vaccination, severe COVID-19, Vitamin D, SARS-COV-2 infection, 25-hydroxyvitamin D, United Arab Emirates, hospital, Human, variant, Infection, COVID-19 severity, immune system, vitamin D deficiency, metabolism, Population, Spread, outcomes, serum, Viral, severity of COVID-19, Genetic variation, Research, Patient, Single-nucleotide polymorphisms, VDR, genetic variants, mechanism of action, Critical, mechanism, association, Vitamin D status, genetic determinants, Genetic variations, genetic determinant, Vitamin D Metabolism, deficiency, Factor, two groups, potential risk, serum 25-hydroxyvitamin D, CYP2R1, genotype data, NADSYN1, Effect, Cell, affected, involved, investigated, implicated, patients with SARS-CoV-2, single-nucleotide, United Arab Emirate, 【제목키워드】 resident,