Abstract Background Concerns have emerged about the higher risk of fatal coronavirus disease 2019 (COVID-19) in cancer patients. In this article, we review the experience of a comprehensive cancer center. Methods A prospective registry was set up at Institut Curie at the beginning of the COVID-19 pandemic. All cancer patients with suspected or proven COVID-19 were entered and actively followed for 28 days. Results Among 9842 patients treated at Institut Curie between March 13 and May 1, 2020, 141 (1.4%) were diagnosed with COVID-19, based on reverse transcription polymerase chain reaction testing and/or computerized tomography scan. In line with our case mix, breast cancer (40.4%) was the most common tumor type, followed by hematological and lung malignancies. Patients with active cancer therapy or/and advanced cancer accounted for 87.9% and 68.9% of patients, respectively. At diagnosis, 78.7% of patients had COVID-19–related symptoms, with an extent of lung parenchyma involvement inferior to 50% in 95.8% of patients. Blood count variations and C-reactive protein elevation were the most common laboratory abnormalities. Antibiotics and antiviral agents were administered in 48.2% and 6.4% of patients, respectively. At the time of analysis, 26 patients (18.4%) have died from COVID-19, and 100 (70.9%) were cured. Independent prognostic factors at the time of COVID-19 diagnosis associated with death or intensive care unit admission were extent of COVID-19 pneumonia and decreased O 2 saturation. Conclusions COVID-19 incidence and presentation in cancer patients appear to be very similar to those in the general population. The outcome of COVID-19 is primarily driven by the initial severity of infection rather than patient or cancer characteristics.
【초록키워드】 COVID-19, coronavirus disease, Tumor, Coronavirus disease 2019, Breast cancer, COVID-19 pneumonia, therapy, intensive care, Pneumonia, COVID-19 pandemic, Cancer, Variation, Diagnosis, lung, C-reactive protein, Antibiotics, outcome, Computerized tomography, polymerase chain reaction, Characteristics, Antiviral agents, Patient, COVID-19 diagnosis, Cancer patients, death, reverse transcription, General population, concern, antiviral agent, Admission, patients, blood count, Analysis, lung parenchyma, Advanced cancer, Prognostic factor, cancer patient, followed by, Chain Reaction, case mix, COVID-19 incidence, Cancer center, higher risk, active cancer, hematological, malignancies, Severity of infection, COVID-19–related symptoms, laboratory abnormalities, Administered, Curie, polymerase chain, initial, Result, died, accounted, cured, driven by, diagnosed with COVID-19, patients treated, 【제목키워드】 SARS-CoV-2,