Dipolar cycloaddition of the N-substituted C -(diethoxyphosphonyl)nitrones with N ^{3}-allyl- N ^{1}-benzylquinazoline-2,4-diones produced mixtures of diastereoisomeric 3-(diethoxyphosphonyl)isoxazolidines with a N ^{1}-benzylquinazoline-2,4-dione unit at C5. The obtained compounds were assessed for antiviral and antibacterial activities. Several compounds showed moderate inhibitory activities against VZV with EC_{50} values in the range of 12.63-58.48 µM. A mixture of isoxazolidines cis – 20c / trans – 20c (6:94) was found to be the most active against B. cereus PCM 1948, showing an MIC value 0.625 mg/mL, and also was not mutagenic up to this concentration.
All Keywords
【저자키워드】 antiviral activity, antimicrobial activity, phosphonates, isoxazolidines, quinazoline-2,4-diones.,
【저자키워드】 antiviral activity, antimicrobial activity, phosphonates, isoxazolidines, quinazoline-2,4-diones.,