Introduction The coronavirus disease 2019 (COVID-19), that is caused by severe acute respiratory syndrome corona virus 2 (SARS-CoV-2), has spread rapidly worldwide since December 2019. The SARS-CoV-2 virus has a great affinity for the angiotensin-converting enzyme-2 (ACE-2) receptor, which is an essential element of the renin-angiotensin system (RAS). This study is aimed at assessing the impact of the angiotensin-converting enzyme (ACE) gene insertion (I)/deletion (D) polymorphisms, on the susceptibility and clinical outcomes of the COVID-19 immunoinflammatory syndrome. Patients and Methods . A total of 112 patients diagnosed with COVID-19 between 1 and 15 May 2020 were enrolled in the study. ACE gene allele frequencies were compared to the previously reported Turkish population comprised of 300 people. Results The most common genotype in the patients and control group was DI with 53% and II with 42%, respectively. The difference in the presence of the D allele between the patient and control groups was statistically significant (67% vs. 42%, respectively, p < 0.0001). Severe pneumonia was observed more in patients with DI allele (31%) than DD (8%) and II (0%) ( p = 0.021). The mortality rate, time to defervescence, and the hospitalization duration were not different between the genotype groups. Conclusion Genotype DI of ACE I/D polymorphism is associated with the infectious rate particularly severe pneumonia in this study conducted in the Turkish population. Therefore, ACE D/I polymorphism could affect the clinical course of COVID-19.
【초록키워드】 COVID-19, coronavirus disease, SARS-CoV-2, Coronavirus disease 2019, Hospitalization, Pneumonia, susceptibility, allele frequency, polymorphism, SARS-CoV-2 virus, virus, RAS, clinical outcomes, Polymorphisms, Clinical outcome, renin-angiotensin system, ACE-2, Spread, Clinical course, Patient, Genotype, receptor, mortality rate, severe pneumonia, respiratory, angiotensin-converting enzyme-2, Angiotensin-converting enzyme, angiotensin, ACE, I/D polymorphism, essential element, acute respiratory syndrome, Renin, control group, defervescence, Severe Acute Respiratory Syndrome Corona Virus, syndrome, allele, insertion, ACE gene, Affect, Result, enrolled, caused, reported, the patient, conducted, groups, statistically significant, not different, diagnosed with COVID-19, time to defervescence, 【제목키워드】 COVID-19, Human,