Viral infections with SARS-CoV-2 can cause a multi-facetted disease, which is not only characterized by pneumonia and overwhelming systemic inflammatory immune responses, but which can also directly affect the digestive system and infect intestinal epithelial cells. Here, we review the current understanding of intestinal tropism of SARS-CoV-2 infection, its impact on mucosal function and immunology and summarize the effect of immune-suppression in patients with inflammatory bowel disease (IBD) on disease outcome of COVID-19 and discuss IBD-relevant implications for the clinical management of SARS-CoV-2 infected individuals.
All Keywords
【초록키워드】 COVID-19, immunology, SARS-CoV-2, Pneumonia, SARS-COV-2 infection, Infection, outcome, viral infections, Inflammatory bowel disease, Viral, immune responses, Patient, Clinical management, epithelial cells, disease, IBD, mucosal, digestive system, SARS-CoV-2 infected individuals, infected individuals, intestinal epithelial cells, infect, Affect, implication, intestinal, systemic inflammatory, characterized, tropism of SARS-CoV-2, 【제목키워드】 Patient, IBD, mucosal,
【초록키워드】 COVID-19, immunology, SARS-CoV-2, Pneumonia, SARS-COV-2 infection, Infection, outcome, viral infections, Inflammatory bowel disease, Viral, immune responses, Patient, Clinical management, epithelial cells, disease, IBD, mucosal, digestive system, SARS-CoV-2 infected individuals, infected individuals, intestinal epithelial cells, infect, Affect, implication, intestinal, systemic inflammatory, characterized, tropism of SARS-CoV-2, 【제목키워드】 Patient, IBD, mucosal,
SARS-CoV-2에 의한 바이러스 감염은 폐렴과 압도적인 전신 염증성 면역 반응을 특징으로 할 뿐만 아니라 소화 시스템에 직접 영향을 미치고 장 상피 세포를 감염시킬 수 있는 다면적 질병을 유발할 수 있습니다. 여기에서 우리는 SARS-CoV-2 감염의 장 친화성, 점막 기능 및 면역학에 대한 영향에 대한 현재 이해를 검토하고 COVID-19의 질병 결과에 대한 염증성 장 질환(IBD) 환자의 면역 억제 효과를 요약합니다. SARS-CoV-2 감염자의 임상 관리에 대한 IBD 관련 영향에 대해 논의합니다.