ABSTRACT SARS-CoV-2 mutations appeared recently and can lead to conformational changes in the spike protein and probably induce modifications in antigenicity. We assessed the neutralizing capacity of antibodies to prevent cell infection, using a live virus neutralization test with different strains [19A (initial one), 20B (B.1.1.241 lineage), 20I/501Y.V1 (B.1.1.7 lineage), and 20H/501Y.V2 (B.1.351 lineage)] in serum samples collected from different populations: two-dose vaccinated COVID-19-naive healthcare workers (HCWs; Pfizer-BioNTech BNT161b2), 6-months post mild COVID-19 HCWs, and critical COVID-19 patients. No significant difference was observed between the 20B and 19A isolates for HCWs with mild COVID-19 and critical patients. However, a significant decrease in neutralization ability was found for 20I/501Y.V1 in comparison with 19A isolate for critical patients and HCWs 6-months post infection. Concerning 20H/501Y.V2, all populations had a significant reduction in neutralizing antibody titers in comparison with the 19A isolate. Interestingly, a significant difference in neutralization capacity was observed for vaccinated HCWs between the two variants but not in the convalescent groups.
【저자키워드】 SARS-CoV-2, Humoral response, variant of concern, 20I/501Y.V1, 20h/501Y.V2, live virus neutralization test, 20B, 【초록키워드】 COVID-19, antibody, B.1.351, neutralization, variant, Infection, healthcare worker, Population, Spike protein, B.1.1.7 lineage, B.1.1.7, HCWs, neutralization test, Patient, Lineage, Mild, neutralizing capacity, antigenicity, SARS-CoV-2 mutation, convalescent, Critical, patients, Pfizer-BioNTech, Antibody titers, Live virus, Neutralizing antibody titer, conformational change, strain, neutralization capacity, HCW, lead, significant difference, no significant difference, serum samples, neutralizing antibody titers, critical patients, significant decrease, modifications, conformational changes, critical COVID-19 patients, Modification, serum sample, post infection, neutralization ability, isolate, Prevent, Cell, BNT161b2, initial, collected, the spike protein, induce, groups, reduction in, 【제목키워드】 Virus neutralization, convalescent patient, subject, isolate,