ABSTRACT Monitoring the humoral protective immune response and its durability after SARS-CoV-2 infections is essential for risk assessment of reinfections, the improvement of diagnostic methods and the evaluation of vaccine trials. We have analyzed neutralizing antibodies and IgG responses specific to different antigens, including the inactivated whole-virion of SARS-CoV-2, the spike subunit 1 protein and its receptor binding domain, as well as the nucleocapsid protein. We show the dynamic developments of the responses from the early convalescent stages up to 9 months post symptoms onset in follow-up samples from 57 COVID-19 patients with varying clinical severity. By correlating antibody signals to neutralizing titres, valid diagnostic markers for the estimation of neutralizing protection could be identified.
【저자키워드】 COVID-19, Neutralizing antibodies, Humoral immunity, inactivated SARS-CoV-2, RBD-ELISA, nucleocapsid-ELISA, S1-ELISA, 【초록키워드】 neutralizing antibody, SARS-CoV-2, Vaccine, Neutralizing antibodies, antibody, SARS-COV-2 infection, diagnostic, risk, nucleocapsid protein, Risk assessment, Receptor binding domain, Protein, response, convalescent stage, antigens, monitoring, Neutralizing, Follow-up, diagnostic methods, estimation, SARS-CoV-2 infections, trials, inactivated, Diagnostic method, marker, Clinical severity, COVID-19 patient, humoral, IgG responses, IgG response, subunit, titres, protective immune response, symptoms onset, analyzed, 【제목키워드】 severity, symptomatic, humoral immune response, SARS-CoV-2 antigen, COVID-19 cohort, virus neutralizing antibody,