Millions of individuals who have recovered from SARS-CoV-2 infection may be eligible to participate in convalescent plasma donor programs, yet the optimal window for donating high neutralizing titer convalescent plasma for COVID-19 immunotherapy remains unknown. Here we studied the response trajectories of antibodies directed to the SARS-CoV-2 surface spike glycoprotein and in vitro SARS-CoV-2 live virus neutralizing titers (VN) in 175 convalescent donors longitudinally sampled for up to 142 days post onset of symptoms (DPO). We observed robust IgM, IgG, and viral neutralization responses to SARS-CoV-2 that persist, in the aggregate, for at least 100 DPO. However, there is a notable decline in VN titers ≥160 for convalescent plasma therapy, starting 60 DPO. The results also show that individuals 30 years of age or younger have significantly lower VN, IgG and IgM antibody titers than those in the older age groups; and individuals with greater disease severity also have significantly higher IgM and IgG antibody titers. Taken together, these findings define the optimal window for donating convalescent plasma useful for immunotherapy of COVID-19 patients and reveal important predictors of an ideal plasma donor. Gontu et al. conducted a longitudinal study in COVID patients in which they assessed the response trajectories of antibodies directed to the SARS-CoV-2 surface spike glycoprotein and in vitro SARS-CoV-2 live virus neutralizing titers. Their measurements demonstrate the presence of an optimum window for convalescent plasma donation as well as predictions of the most suitable donor type.
【저자키워드】 Applied immunology, Immunotherapy, breath, 【초록키워드】 COVID-19, convalescent plasma, SARS-CoV-2, IgG, IgM, antibody, Immunotherapy, SARS-COV-2 infection, disease severity, spike glycoprotein, in vitro, IgG antibody, Viral, Convalescent plasma therapy, longitudinal study, response, Older age, Antibody titer, trajectory, plasma, age, glycoprotein, viral neutralization, predictor, convalescent, Antibody titers, Live virus, Donor, Neutralizing titer, COVID-19 patient, titers, IgG and IgM, IgM and IgG, IgM antibody, individual, IgG antibody titers, neutralizing titers, Covid patients, aggregate, significantly lower, robust, greater, conducted, onset of symptom, significantly higher, notable, COVID patient, eligible, the SARS-CoV-2, 【제목키워드】 COVID-19, Antibody titers, Neutralizing antibody titer, Limited,