It is now established that a protein can switch between multiple conformations to enable altered functions. Several pathogens including SARS COV2 utilize context-dependent conformational switches of particular proteins to invade host membrane to establish infections. In this perspective, we first discuss the understanding of the conformational switch of a protein towards the productive infections as a dark side of nature. Next, the unexplored binary combination of the sequences of SARS COV2 spike protein and the similarity with diverse pathogen derived proteins have been discussed to obtain novel molecular insights into the process of infection. Sannigrahi et al. discuss conformational switching that allows proteins to alter their conformation, aiding in pathogenesis by enabling cellular entry of viruses and bacterial toxins. Focussing on fusion domain of the Spike glycoprotein of SARS COV2 virus, they identify similar “switching sequences” present in diverse pathogen derived proteins.
【저자키워드】 structural biology, Proteins, Protein sequence analyses, 【초록키워드】 viruses, Pathogenesis, spike glycoprotein, Infection, virus, Spike protein, Protein, infections, pathogen, membrane, Pathogens, glycoprotein, cellular entry, molecular, Bacterial, Combination, similarity, switching, derived proteins, bacterial toxins, Perspective, sequences, domain, sequence, conformation, functions, toxins, Host, Alter, identify, conformational, the Spike, 【제목키워드】 Infection, Protein, conformational,