Objectives: There have been reports on re-detectable positive nucleic acid tests for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in recovered coronavirus disease (COVID-19) patients. In this study, we look at the clinical characteristics, possible causes, pathogenesis, and infectivity of re-detectable positive patients and provide up-to-date information to public health policy planners and clinicians. Methods: By consulting the latest research data and related progress data of re-detectable positive patients, this study addresses the implications that this special group brings to clinical work and disease prevention and control. Results: We discuss in detail the phenomenon of re-detectable positive nucleic acid tests for recovered patients. There are many possible causes of a re-detectable positive, but there is no 1 factor that can fully explain this phenomenon. Conclusions: It can’t be completely ruled out that the re-detectable positive patients are infectious. We should be alert to these re-detectable positive patients becoming chronic virus carriers, and virus serological IgM and IgG antibody tests should be added before patient discharge. It is urgent to find a more powerful evidence-based and virological basis for the integrity of viral ribonucleic acid and the variation of viral virulence with time through cell experiments in vitro and animal experiments in vivo.
【저자키워드】 COVID-19, SARS-CoV-2, Re-detectable positive, 【초록키워드】 coronavirus disease, public health, coronavirus, Pathogenesis, Clinical characteristics, Variation, Health policy, in vitro, severe acute respiratory syndrome Coronavirus, virus, discharge, nucleic acid, IgG antibody, Viral, animal experiments, antibody tests, nucleic acid test, Research, Patient, Antibody test, experiment, recovered patients, infectious, respiratory, in vivo, information, serological, disease, patients, Viral virulence, Prevention and control, IgM and IgG, Ribonucleic acid, virus carriers, special group, Clinicians, acute respiratory syndrome, Virological, acute respiratory syndrome coronavirus, acute respiratory syndrome coronavirus 2, carriers, phenomenon, viral ribonucleic acid, causes, positive patients, integrity, positive, implication, Cell, added, cause, explain, positive patient, 【제목키워드】 recovered, acid, Result,