A 72-year-old immunocompromised man infected with severe acute respiratory syndrome coronavirus 2 received bamlanivimab monotherapy. Viral evolution was monitored in nasopharyngeal and blood samples by melting curve analysis of single-nucleotide polymorphisms and whole-genome sequencing. Rapid emergence of spike receptor binding domain mutations was found, associated with a compartmentalization of viral populations.
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【저자키워드】 COVID-19, coronavirus disease, severe acute respiratory syndrome coronavirus 2, viruses, respiratory infections, zoonoses, whole-genome sequencing, SARS-CoV-2, Coronaviruses, Immunotherapy, monoclonal antibody, variants, bamlanivimab, Selection, monotherapy, compartmentalization, 【초록키워드】 severe acute respiratory syndrome coronavirus 2, whole-genome sequencing, Evolution, coronavirus, Mutation, polymorphism, severe acute respiratory syndrome Coronavirus, bamlanivimab, Receptor binding domain, Viral, nasopharyngeal, viral evolution, Single-nucleotide polymorphisms, Immunocompromised, Rapid, melting curve analysis, respiratory, acute respiratory syndrome, Spike receptor binding domain, acute respiratory syndrome coronavirus, Blood samples, blood sample, populations, single-nucleotide,
【저자키워드】 COVID-19, coronavirus disease, severe acute respiratory syndrome coronavirus 2, viruses, respiratory infections, zoonoses, whole-genome sequencing, SARS-CoV-2, Coronaviruses, Immunotherapy, monoclonal antibody, variants, bamlanivimab, Selection, monotherapy, compartmentalization, 【초록키워드】 severe acute respiratory syndrome coronavirus 2, whole-genome sequencing, Evolution, coronavirus, Mutation, polymorphism, severe acute respiratory syndrome Coronavirus, bamlanivimab, Receptor binding domain, Viral, nasopharyngeal, viral evolution, Single-nucleotide polymorphisms, Immunocompromised, Rapid, melting curve analysis, respiratory, acute respiratory syndrome, Spike receptor binding domain, acute respiratory syndrome coronavirus, Blood samples, blood sample, populations, single-nucleotide,
중증급성호흡기증후군 코로나바이러스 2에 감염된 72세 면역저하남이 밤라니비맙 단독요법을 받았다. 단일 뉴클레오티드 다형성 및 전체 게놈 시퀀싱의 용융 곡선 분석을 통해 비인두 및 혈액 샘플에서 바이러스 진화를 모니터링했습니다. 바이러스 집단의 구획화와 관련된 스파이크 수용체 결합 도메인 돌연변이의 급속한 출현이 발견되었습니다.