We aimed to generate an unbiased estimate of the incidence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in 4 urban counties in Utah, USA. We used a multistage sampling design to randomly select community-representative participants > 12 years of age. During May 4–June 30, 2020, we collected serum samples and survey responses from 8,108 persons belonging to 5,125 households. We used a qualitative chemiluminescent microparticle immunoassay to detect SARS-CoV-2 IgG in serum samples. We estimated the overall seroprevalence to be 0.8%. The estimated seroprevalence-to-case count ratio was 2.5, corresponding to a detection fraction of 40%. Only 0.2% of participants from whom we collected nasopharyngeal swab samples had SARS-CoV-2–positive reverse transcription PCR results. SARS-CoV-2 antibody prevalence during the study was low, and prevalence of PCR-positive cases was even lower. The comparatively high SARS-CoV-2 detection rate (40%) demonstrates the effectiveness of Utah’s testing strategy and public health response.
【저자키워드】 COVID-19, coronavirus disease, severe acute respiratory syndrome coronavirus 2, viruses, respiratory infections, zoonoses, antibodies, SARS-CoV-2, IgG, coronavirus, serology, SARS, Seroprevalence, sensitivity, specificity, rRT-PCR, Immunoglobulin G, infections, PCR, nasopharyngeal swabs, population surveillance, Seroepidemiologic studies, United States, incidence, case detection, reverse transcription PCR, probability sampling design, Utah, 【초록키워드】 public health, coronavirus, Infection, severe acute respiratory syndrome Coronavirus, Prevalence, Nasopharyngeal swab, immunoassay, SARS-CoV-2 detection, SARS-CoV-2 antibody, response, Effectiveness, age, respiratory, USA, Utah, detection rate, SARS-CoV-2 IgG, Nasopharyngeal swab samples, acute respiratory syndrome, unbiased estimate, acute respiratory syndrome coronavirus, serum samples, acute respiratory syndrome coronavirus 2, PCR-positive, participant, fraction, nasopharyngeal swab sample, serum sample, Microparticle, Randomly, detect, collected, generate, SARS-CoV-2–positive, 【제목키워드】 coronavirus, detection, coronavirus 2, USA, estimate,