Objective: To detect serum Type IV collagen levels in patients with various hepatic diseases.
Method: A sandwich enzyme-immunoassay, using two monoclonal antibodies to recognize 7S and TH of Type IV collage, was used to detect serum levels of Type IV collagen in 428 patients with various liver diseases.
Results: Serum levels of Type IV collagen in healthy control subjects were (63.2 +/- 31.9) microgram.L-1. Type IV collagen levels in the serum of patients with heavy hepatitis were the highest [(801.8 +/- 431.2) microgram.L-1]. All Types of hepatic diseases were significantly higher than those in healthy subjects (All P < 0.01).
Conclusion: The assay used in this study is simple and practical and can be applied to clinical evaluation of hepatic fibrosis.
[Detection of serum type IV collagen and the alteration of this collagen in various liver diseases]
[Category] A형 간염,
[Source] pubmed
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