The dynamics underlying severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) reinfection remain poorly understood. We identified a small cluster of patients in Brazil who experienced 2 episodes of coronavirus disease (COVID-19) in March and late May 2020. In the first episode, patients manifested an enhanced innate response compared with healthy persons, but neutralizing humoral immunity was not fully achieved. The second episode was associated with different SARS-CoV-2 strains, higher viral loads, and clinical symptoms. Our finding that persons with mild COVID-19 may have controlled SARS-CoV-2 replication without developing detectable humoral immunity suggests that reinfection is more frequent than supposed, but this hypothesis is not well documented.
【저자키워드】 COVID-19, coronavirus disease, severe acute respiratory syndrome coronavirus 2, viruses, respiratory infections, zoonoses, Brazil, SARS-CoV-2, Reinfection, Humoral response, Next-generation sequencing, 【초록키워드】 coronavirus disease, Brazil, coronavirus, Clinical symptoms, severe acute respiratory syndrome Coronavirus, Humoral immunity, Viral, Patient, Cluster, Mild, Neutralizing, respiratory, SARS-CoV-2 replication, Hypothesis, first episode, innate response, acute respiratory syndrome, acute respiratory syndrome coronavirus, acute respiratory syndrome coronavirus 2, viral loads, SARS-CoV-2 strains, healthy, detectable, manifested, 【제목키워드】 response, Person,