Infections with the Omicron SARS-CoV-2 variant are rapidly increasing worldwide. Among 174,349 SARS-CoV-2-infected individuals (≥ 12 years), we observed an increased risk of S gene target failure, predictive of the Omicron variant, in vaccinated (odds ratio (OR): 3.6; 95% confidence interval (CI): 3.4–3.7) and previously infected individuals (OR: 4.2; 95% CI: 3.8–4.7) compared with infected naïve individuals. This suggests vaccine- or infection-induced immunity against SARS-CoV-2 infections is less effective against the Omicron than the Delta variant.
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【저자키워드】 Epidemiology, viral infections, Laboratory, air-borne infections, severe acute respiratory syndrome - SARS, vaccines and immunisation, SARS-CoV-2 Omicron Variant of Concern Vaccine escape, 【초록키워드】 Vaccine, Immunity, SARS-COV-2 infection, variant, SARS-CoV-2 variant, omicron, delta variant, Omicron variant, SARS-CoV-2 infections, S gene, Odds ratio, Predictive, 95% confidence interval, increased risk, infected individual, infected individuals, naïve individuals, S gene target failure, effective, less, SARS-CoV-2-infected individual, 【제목키워드】 SARS-CoV-2, Delta, risk of infection, Netherlands, Increased,
【저자키워드】 Epidemiology, viral infections, Laboratory, air-borne infections, severe acute respiratory syndrome - SARS, vaccines and immunisation, SARS-CoV-2 Omicron Variant of Concern Vaccine escape, 【초록키워드】 Vaccine, Immunity, SARS-COV-2 infection, variant, SARS-CoV-2 variant, omicron, delta variant, Omicron variant, SARS-CoV-2 infections, S gene, Odds ratio, Predictive, 95% confidence interval, increased risk, infected individual, infected individuals, naïve individuals, S gene target failure, effective, less, SARS-CoV-2-infected individual, 【제목키워드】 SARS-CoV-2, Delta, risk of infection, Netherlands, Increased,
Omicron SARS-CoV-2 변종 감염이 전 세계적으로 빠르게 증가하고 있습니다. SARS-CoV-2에 감염된 174,349명의 개인(≥ 12년) 중, 우리는 백신 접종에서 Omicron 변이를 예측하는 S 유전자 표적 실패의 위험 증가를 관찰했습니다(교차비(OR): 3.6; 95% 신뢰 구간(CI ): 3.4–3.7) 및 이전에 감염된 개인(OR: 4.2; 95% CI: 3.8–4.7)과 감염된 경험이 없는 개인. 이는 SARS-CoV-2 감염에 대한 백신 또는 감염 유도 면역이 Delta 변이체보다 Omicron에 대해 덜 효과적임을 시사합니다.