Two new SARS-CoV-2 lineages with the N501Y mutation in the receptor-binding domain of the spike protein spread rapidly in the United Kingdom. We estimated that the earlier 501Y lineage without amino acid deletion Δ69/Δ70, circulating mainly between early September and mid-November, was 10% (6–13%) more transmissible than the 501N lineage, and the 501Y lineage with amino acid deletion Δ69/Δ70, circulating since late September, was 75% (70–80%) more transmissible than the 501N lineage.
All Keywords
【저자키워드】 COVID-19, SARS-CoV-2, Spike protein, Transmissibility, N501Y, VOC-202012/01, fitness, Lineage B.1.1.7, United Kingdom, 20B/501Y.V1, 【초록키워드】 Spike protein, Spread, Receptor-binding domain, Lineage, N501Y mutation, United Kingdom, Amino acid, circulating, new SARS-CoV-2, the spike protein, the receptor-binding domain, 【제목키워드】 United Kingdom, mutant strain,
【저자키워드】 COVID-19, SARS-CoV-2, Spike protein, Transmissibility, N501Y, VOC-202012/01, fitness, Lineage B.1.1.7, United Kingdom, 20B/501Y.V1, 【초록키워드】 Spike protein, Spread, Receptor-binding domain, Lineage, N501Y mutation, United Kingdom, Amino acid, circulating, new SARS-CoV-2, the spike protein, the receptor-binding domain, 【제목키워드】 United Kingdom, mutant strain,
스파이크 단백질의 수용체 결합 도메인에 N501Y 돌연변이가 있는 두 개의 새로운 SARS-CoV-2 계통이 영국에서 빠르게 퍼졌습니다. 우리는 주로 9월 초와 11월 중순 사이에 순환하는 아미노산 결손이 없는 초기 501Y 계통 Δ69/Δ70이 501N 계통과 아미노산 결손이 있는 501Y 계통 Δ69보다 10%(6-13%) 더 전염성이 있다고 추정했습니다. /Δ70은 9월 말부터 유통되며 501N 계통보다 75%(70~80%) 더 전염성이 높습니다.