SARS-CoV-2 variants of concern (VOC) should not escape molecular surveillance. We investigated if SARS-CoV-2 rapid antigen tests (RATs) could detect B.1.1.7 and B.1.351 VOCs in certain laboratory conditions. Infectious cell culture supernatants containing B.1.1.7, B.1.351 or non-VOC SARS-CoV-2 were respectively diluted both in DMEM and saliva. Dilutions were analysed with Roche, Siemens, Abbott, nal von minden and RapiGEN RATs. While further studies with appropriate real-life clinical samples are warranted, all RATs detected B.1.1.7 and B.1.351, generally comparable to non-VOC strain.
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【저자키워드】 SARS-CoV-2, B.1.351, B.1.1.7, performance, Rapid antigen test(s), Variant(s) of Concern, 【초록키워드】 Saliva, VoC, B.1.351, SARS-CoV-2 variant, Laboratory, Rapid antigen tests, rapid antigen test, Surveillance, SARS-CoV-2 variants, B.1.1.7, molecular, Roche, RAT, Abbott, RATs, Siemens, dilutions, RapiGEN, while, cell culture supernatant, DMEM, nal von minden, clinical sample, detect, investigated, analysed, comparable, conditions, 【제목키워드】 variants of concern, detection, rapid antigen test, Germany, FIVE, new SARS-CoV-2,
【저자키워드】 SARS-CoV-2, B.1.351, B.1.1.7, performance, Rapid antigen test(s), Variant(s) of Concern, 【초록키워드】 Saliva, VoC, B.1.351, SARS-CoV-2 variant, Laboratory, Rapid antigen tests, rapid antigen test, Surveillance, SARS-CoV-2 variants, B.1.1.7, molecular, Roche, RAT, Abbott, RATs, Siemens, dilutions, RapiGEN, while, cell culture supernatant, DMEM, nal von minden, clinical sample, detect, investigated, analysed, comparable, conditions, 【제목키워드】 variants of concern, detection, rapid antigen test, Germany, FIVE, new SARS-CoV-2,
SARS-CoV-2 관련 변종(VOC)은 분자 감시를 벗어나서는 안 됩니다. 우리는 SARS-CoV-2 급속 항원 검사(RAT)가 특정 실험실 조건에서 B.1.1.7 및 B.1.351 VOC를 검출할 수 있는지 조사했습니다. B.1.1.7, B.1.351 또는 non-VOC SARS-CoV-2를 함유하는 감염성 세포 배양 상청액을 각각 DMEM과 타액에 희석했습니다. 희석액은 Roche, Siemens, Abbott, nal von minden 및 RapiGEN RAT로 분석되었습니다. 적절한 실제 임상 샘플을 사용한 추가 연구가 필요하지만 모든 RAT는 B.1.1.7 및 B.1.351을 검출했으며 일반적으로 비 VOC 균주와 유사합니다.