Several factors may account for the recent increased spread of the SARS-CoV-2 Delta sub-lineage AY.4.2 in the United Kingdom, Romania, Poland, and Denmark. We evaluated the sensitivity of AY.4.2 to neutralisation by sera from 30 Comirnaty (BNT162b2 mRNA) vaccine recipients in Denmark in November 2021. AY.4.2 neutralisation was comparable to other circulating Delta lineages or sub-lineages. Conversely, the less prevalent B.1.617.2 with E484K showed a significant more than 4-fold reduction in neutralisation that warrants surveillance of strains with the acquired E484K mutation.
All Keywords
【저자키워드】 COVID-19, SARS-CoV-2, coronavirus, variant, Delta, Virus neutralization, E484K mutation, AY.4.2, 【초록키워드】 Vaccine, Poland, BNT162b2, Spread, sensitivity, Surveillance, sera, Lineage, E484K, Romania, United Kingdom, Denmark, lineages, Strains, neutralisation, BNT162b2 mRNA, strain, Factor, circulating, recipient, prevalent, evaluated, less, comparable, reduction in, the SARS-CoV-2, 【제목키워드】 Mutation, B.1.617.2, delta variant, the SARS-CoV-2,
【저자키워드】 COVID-19, SARS-CoV-2, coronavirus, variant, Delta, Virus neutralization, E484K mutation, AY.4.2, 【초록키워드】 Vaccine, Poland, BNT162b2, Spread, sensitivity, Surveillance, sera, Lineage, E484K, Romania, United Kingdom, Denmark, lineages, Strains, neutralisation, BNT162b2 mRNA, strain, Factor, circulating, recipient, prevalent, evaluated, less, comparable, reduction in, the SARS-CoV-2, 【제목키워드】 Mutation, B.1.617.2, delta variant, the SARS-CoV-2,
영국, 루마니아, 폴란드 및 덴마크에서 최근 SARS-CoV-2 Delta 하위 계통 AY.4.2의 확산이 증가한 데에는 몇 가지 요인이 있을 수 있습니다. 우리는 2021년 11월 덴마크에서 30명의 Comirnaty(BNT162b2 mRNA) 백신 수혜자의 혈청에 의한 중화에 대한 AY.4.2의 민감성을 평가했습니다. AY.4.2 중화는 순환하는 다른 Delta 계통 또는 하위 계통과 비슷했습니다. 반대로, E484K가 있는 덜 널리 퍼진 B.1.617.2는 중화에서 4배 이상의 유의미한 감소를 보여 획득한 E484K 돌연변이가 있는 균주의 감시를 보장합니다.