Here, we describe the case of a COVID-19 patient who developed recurring ventilator-associated pneumonia caused by Pseudomonas aeruginosa that acquired increasing levels of antimicrobial resistance (AMR) in response to treatment. Metagenomic analysis revealed the AMR genotype, while immunological analysis revealed massive and escalating levels of T-cell activation. These were both SARS-CoV-2 and P. aeruginosa specific, and bystander activated, which may have contributed to this patient’s persistent symptoms and radiological changes.
All Keywords
【저자키워드】 SARS-CoV-2, Human, metagenomics, t-cells activation, Pseudomonas aeruginosa, 【초록키워드】 Treatment, Pneumonia, Symptom, antimicrobial resistance, Genotype, Analysis, Pseudomonas aeruginosa, COVID-19 patient, Ventilator-associated pneumonia, response to treatment, changes, bystander, T-cell activation, P. aeruginosa, immunological, radiological, caused, activated, contributed, 【제목키워드】 COVID-19, Pneumonia, Bacterial, Evidence,
【저자키워드】 SARS-CoV-2, Human, metagenomics, t-cells activation, Pseudomonas aeruginosa, 【초록키워드】 Treatment, Pneumonia, Symptom, antimicrobial resistance, Genotype, Analysis, Pseudomonas aeruginosa, COVID-19 patient, Ventilator-associated pneumonia, response to treatment, changes, bystander, T-cell activation, P. aeruginosa, immunological, radiological, caused, activated, contributed, 【제목키워드】 COVID-19, Pneumonia, Bacterial, Evidence,
여기에서는 치료에 대한 반응으로 증가하는 수준의 항균제 내성(AMR)을 획득한 녹농균으로 인한 인공호흡기 관련 폐렴의 재발이 발생한 COVID-19 환자의 사례를 설명합니다. 메타게놈 분석은 AMR 유전자형을 밝혀냈고, 면역학적 분석은 T 세포 활성화의 거대하고 증가하는 수준을 보여주었습니다. 이들은 SARS-CoV-2 및 P. aeruginosa에 특이적이고 방관자가 활성화되어 이 환자의 지속적인 증상과 방사선학적 변화에 기여했을 수 있습니다.