Objectives: JAK kinase inhibitors (JAKi) are a new therapeutic option in the treatment of rheumatoid arthritis, but they are not without risks, especially the incidence of herpes zoster (HZ).
Material and methods: Systematic literature review that evaluates the incidence of HZ published in the clinical trials of the different JAK is marketed or under study.
Results: The HZ rates ranged between 1.51 and 20.22. The results were expressed mainly as a percentage of events. The most recent studies better categorized the incidence of HZ and its severity.
Conclusion: JAK is are associated with an increased risk of HZ. Although the HZ rates of the selective JAK1 JAK is are lower, more studies are needed to confirm these results.
【저자키워드】 jak inhibitors, rheumatoid arthritis., herpes zoster, Artritis reumatoide, Inhibidores de JAK,