[저자] Salwa Naushin, Viren Sardana, Rajat Ujjainiya, Nitin Bhatheja, Rintu Kutum, Akash Kumar Bhaskar, Shalini Pradhan, Satyartha Prakash, Raju Khan, Birendra Singh Rawat, Karthik Bharadwaj Tallapaka, Mahesh Anumalla, Giriraj Ratan Chandak, Amit Lahiri, Susanta Kar, Shrikant Ramesh Mulay, Madhav Nilakanth Mugale, Mrigank Srivastava, Shaziya Khan, Anjali Srivastava, Bhawana Tomar, Murugan Veerapandian, Ganesh Venkatachalam, Selvamani Raja Vijayakumar, Ajay Agarwal, Dinesh Gupta, Prakash M Halami, Muthukumar Serva Peddha, Gopinath M Sundaram, Ravindra P Veeranna, Anirban Pal, Vinay Kumar Agarwal, Anil Ku Maurya, Ranvijay Kumar Singh, Ashok Kumar Raman, Suresh Kumar Anandasadagopan, Parimala Karuppanan, Subramanian Venkatesan, Harish Kumar Sardana, Anamika Kothari, Rishabh Jain, Anupama Thakur, Devendra Singh Parihar, Anas Saifi, Jasleen Kaur, Virendra Kumar, Avinash Mishra, Iranna Gogeri, Geethavani Rayasam, Praveen Singh, Rahul Chakraborty, Gaura Chaturvedi, Pinreddy Karunakar, Rohit Yadav, Sunanda Singhmar, Dayanidhi Singh, Sharmistha Sarkar, Purbasha Bhattacharya, Sundaram Acharya, Vandana Singh, Shweta Verma, Drishti Soni, Surabhi Seth, Sakshi Vashisht, Sarita Thakran, Firdaus Fatima, Akash Pratap Singh, Akanksha Sharma, Babita Sharma, Manikandan Subramanian, Yogendra S Padwad, Vipin Hallan, Vikram Patial, Damanpreet Singh, Narendra Vijay Tripude, Partha Chakrabarti, Sujay Krishna Maity, Dipyaman Ganguly, Jit Sarkar, Sistla Ramakrishna, Balthu Narender Kumar, Kiran A Kumar, Sumit G Gandhi, Piyush Singh Jamwal, Rekha Chouhan, Vijay Lakshmi Jamwal, Nitika Kapoor, Debashish Ghosh, Ghanshyam Thakkar, Umakanta Subudhi, Pradip Sen, Saumya Ray Chaudhury, Rashmi Kumar, Pawan Gupta, Amit Tuli, Deepak Sharma, Rajesh P Ringe, Amarnarayan D, Mahesh Kulkarni, Dhansekaran Shanmugam, Mahesh S Dharne, Sayed G Dastager, Rakesh Joshi, Amita P Patil, Sachin N Mahajan, Abujunaid Habib Khan, Vasudev Wagh, Rakesh Kumar Yadav, Ajinkya Khilari, Mayuri Bhadange, Arvindkumar H Chaurasiya, Shabda E Kulsange, Krishna Khairnar, Shilpa Paranjape, Jatin Kalita, Narahari G Sastry, Tridip Phukan, Prasenjit Manna, Wahengbam Romi, Pankaj Bharali, Dibyajyoti Ozah, Ravi Kumar Sahu, Elapavalooru VSSK Babu, Rajeev Sukumaran, Aiswarya R Nair, Prajeesh Kooloth Valappil, Anoop Puthiyamadam, Adarsh Velayudhanpillai, Kalpana Chodankar, Samir Damare, Yennapu Madhavi, Ved Varun Aggarwal, Sumit Dahiya, Anurag Agrawal, Debasis Dash, Shantanu Sengupta
[Category] MERS, SARS, 바이오마커, 진단, 치료법,
[Article Type] Multicenter Study
[Source] PMC
To understand the spread of SARS-CoV2, in August and September 2020, the Council of Scientific and Industrial Research (India) conducted a serosurvey across its constituent laboratories and centers across India. Of 10,427 volunteers, 1058 (10.14%) tested positive for SARS-CoV2 anti-nucleocapsid (anti-NC) antibodies, 95% of which had surrogate neutralization activity. Three-fourth of these recalled no symptoms. Repeat serology tests at 3 (n = 607) and 6 (n = 175) months showed stable anti-NC antibodies but declining neutralization activity. Local seropositivity was higher in densely populated cities and was inversely correlated with a 30-day change in regional test positivity rates (TPRs). Regional seropositivity above 10% was associated with declining TPR. Personal factors associated with higher odds of seropositivity were high-exposure work (odds ratio, 95% confidence interval, p value: 2.23, 1.92–2.59, <0.0001), use of public transport (1.79, 1.43–2.24, <0.0001), not smoking (1.52, 1.16–1.99, 0.0257), non-vegetarian diet (1.67, 1.41–1.99, <0.0001), and B blood group (1.36, 1.15–1.61, 0.001).
All Keywords
【저자키워드】 neutralizing antibody, SARS-CoV2, virus, Sero-prevalence, Other, antibody stability, 【초록키워드】 antibodies, antibody, India, smoking, Laboratory, Spread, Serosurvey, serology tests, Seropositivity, serology test, public transport, volunteers, Blood Group, Odds ratio, Repeat, no symptoms, p value, Transport, Factor, 95% confidence interval, higher odds, neutralization activity, positive, Council, Regional, Industrial, tested, conducted, correlated, recalled, declining, higher odd, TPR, 【제목키워드】 insight, Pan,
SARS-CoV2의 확산을 이해하기 위해 2020년 8월과 9월에 과학 및 산업 연구 위원회(인도)는 인도 전역의 구성 연구소와 센터에서 혈청 조사를 실시했습니다. 10,427명의 지원자 중 1058명(10.14%)이 SARS-CoV2 항-뉴클레오캡시드(항-NC) 항체에 대해 양성 반응을 보였고, 이 중 95%는 대리 중화 활성을 보였습니다. 이들 중 4분의 3은 아무런 증상도 기억하지 못했다. 3(n = 607) 및 6(n = 175) 개월에 혈청학 검사를 반복한 결과 안정적인 항-NC 항체가 나타났지만 중화 활성은 감소했습니다. 지역 혈청 양성은 인구 밀도가 높은 도시에서 더 높았고 지역 검사 양성률(TPR)의 30일 변화와 반비례했습니다. 10% 이상의 국소 혈청 양성은 TPR 감소와 관련이 있습니다. 혈청 양성 반응의 더 높은 확률과 관련된 개인적 요인은 높은 노출 작업(승산비, 95% 신뢰 구간, p 값: 2.23, 1.92–2.59, <0.0001), 대중 교통 이용(1.79, 1.43–2.24, <0.0001), 금연(1.52, 1.16–1.99, 0.0257), 비채식주의자(1.67, 1.41–1.99, <0.0001) 및 B 혈액형(1.36, 1.15–1.61, 0.001).