The identification of genetic variation that directly impacts infection susceptibility to SARS-CoV-2 and disease severity of COVID-19 is an important step towards risk stratification, personalized treatment plans, therapeutic, and vaccine development and deployment. Given the importance of study design in infectious disease genetic epidemiology, we use simulation and draw on current estimates of exposure, infectivity, and test accuracy of COVID-19 to demonstrate the feasibility of detecting host genetic factors associated with susceptibility and severity in published COVID-19 study designs. We demonstrate that limited phenotypic data and exposure/infection information in the early stages of the pandemic significantly impact the ability to detect most genetic variants with moderate effect sizes, especially when studying susceptibility to SARS-CoV-2 infection. Our insights can aid in the interpretation of genetic findings emerging in the literature and guide the design of future host genetic studies. Supplementary Information The online version contains supplementary material available at 10.1186/s13073-020-00818-2.
【저자키워드】 Genome-wide association studies, Study design, Genetic epidemiology, Statistical genetics, 【초록키워드】 COVID-19, Treatment, SARS-CoV-2, Vaccine development, pandemic, Epidemiology, feasibility, SARS-COV-2 infection, susceptibility, severity, disease severity, Genetic, Infection, Infectious disease, risk stratification, Simulation, Accuracy, Impact, Genetic variation, therapeutic, Interpretation, Study design, Genetic variant, estimate, information, Genetic epidemiology, moderate, early stage, genetic findings, genetic factors, Factor, supplementary material, effect sizes, early stages, Genetic studies, phenotypic data, disease severity of COVID-19, Host, detect, significantly, genetic finding, 【제목키워드】 COVID-19, Case-control, genomic, Host,