Coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), is associated with a high mortality rate. The majority of deaths in this disease are caused by ARDS (acute respiratory distress syndrome) followed by cytokine storm and coagulation complications. Although alterations in the level of the number of coagulation factors have been detected in samples from COVID-19 patients, the direct molecular mechanism which has been involved in this pathologic process has not been explored yet. The PI3K/AKT signaling pathway is an intracellular pathway which plays a central role in cell survival. Also, in recent years the association between this pathway and coagulopathies has been well clarified. Therefore, based on the evidence on over-activity of the PI3K/AKT signaling pathway in SARS-CoV-2 infection, in the current review, the probable role of this cellular pathway as a therapeutic target for the prevention of coagulation complications in patients with COVID-19 is discussed.
【저자키워드】 COVID-19, SARS-CoV-2, Coagulation, PI3K/AKT, 【초록키워드】 coronavirus disease, Coronavirus disease 2019, ARDS, Cytokine storm, acute respiratory distress syndrome, SARS-COV-2 infection, cytokine, molecular mechanism, severe acute respiratory syndrome Coronavirus, Coagulation, Coagulopathy, Severe acute respiratory syndrome, survival, death, pathway, Complication, complications, signaling pathway, Coagulation factors, respiratory, Coagulopathies, disease, COVID-19 patients, association, acute respiratory distress, Coronavirus-2, Evidence, therapeutic target, followed by, respiratory distress, coagulation factor, acute respiratory syndrome, acute respiratory syndrome coronavirus, alteration, acute respiratory syndrome coronavirus-2, syndrome, PI3K, high mortality rate, cellular pathway, cell survival, Cell, caused, involved, majority, pathologic process, patients with COVID-19, 【제목키워드】 Coagulopathy, signaling pathway, therapeutic potential,