Aim: To understand the pathological progress of COVID-19 and to explore the potential biomarkers. Background: The COVID-19 pandemic is ongoing. There is metabolomics research about COVID-19 indicating the rich information of metabolomics is worthy of further data mining. Methods: We applied bioinformatics technology to reanalyze the published metabolomics data of COVID-19. Results: Benzoate, β-alanine and 4-chlorobenzoic acid were first reported to be used as potential biomarkers to distinguish COVID-19 patients from healthy individuals; taurochenodeoxycholic acid 3-sulfate, glucuronate and N,N,N-trimethyl-alanylproline betaine TMAP are the top classifiers in the receiver operating characteristic curve of COVID-severe and COVID-nonsevere patients. Conclusion: These unique metabolites suggest an underlying immunoregulatory treatment strategy for COVID-19.
【저자키워드】 COVID-19, immune response, Biomarkers, metabolomic profiling, 【초록키워드】 Treatment, metabolomics, COVID-19 pandemic, bioinformatics, information, patients, metabolite, COVID-19 patients, Potential biomarker, COVID-19 patient, betaine, receiver operating characteristic, sulfate, Classifier, healthy individuals, Alanine, potential biomarkers, glucuronate, taurochenodeoxycholic acid, β-alanine, healthy, reported, applied, unique, 【제목키워드】 Potential biomarker,