The coronavirus disease 19 (COVID-19) pandemic poses a serious global threat to human health and the economy. Based on accumulating evidence, its continuous progression involves not only pulmonary injury but also damage to the cardiovascular system due to intertwined pathophysiological risks. As a point of convergence in the pathophysiologic process between COVID-19 and heart failure (HF), cytokine storm induces the progression of COVID-19 in patients presenting pre-existing or new onset myocardial damage and even HF. Cytokine storm, as a trigger of the progression of HF in patients with COVID-19, has become a novel focus to explore therapies for target populations. In this review, we briefly introduce the basis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and illuminate the mechanism and links among COVID-19, cytokine storm, and HF. Furthermore, we discuss drugs and therapeutic targets for patients with COVID-19 and HF.
【저자키워드】 COVID-19, Treatment, Cytokine storm, heart failure, 【초록키워드】 coronavirus disease, SARS-CoV-2, Cytokine storm, coronavirus, pandemic, therapy, Economy, cytokine, drug, cardiovascular system, progression, severe acute respiratory syndrome Coronavirus, heart failure, Health, myocardial damage, pulmonary injury, respiratory, mechanism, convergence, therapeutic targets, Evidence, Trigger, therapeutic target, focus, target populations, point of convergence, acute respiratory syndrome, acute respiratory syndrome coronavirus, acute respiratory syndrome coronavirus 2, pathophysiologic process, populations, induce, presenting, accumulating, COVID-19 in patient, pathophysiological, patients with COVID-19, 【제목키워드】 cytokine, heart, failure, storm,