There has been strong evidence of myocardial injury in coronavirus disease 2019 (COVID-19) patients with significantly elevated serum cardiac troponin (cTn). While the exact mechanism of injury is unclear, possible suggested pathological mechanisms of injury are discussed. These include increased susceptibility of the myocardium and endothelium to viral invasion, underlying hyperinflammatory state and subsequent cytokine storm, a hypercoagulable and prothrombotic state, and indirect myocardial injury due to hypoxemia. As a result of these pathological mechanisms in COVID-19 patients, cTn may be elevated largely due to myocarditis, microangiopathy or myocardial infarction. The utility of cTn as a biomarker for measuring myocardial injury in these patients and assessing its ability as a prognostic factor for clinical outcome is also discussed.
【저자키워드】 COVID-19, cardiovascular diseases, cardiac troponin, 【초록키워드】 coronavirus disease, Coronavirus disease 2019, Cytokine storm, Biomarker, susceptibility, cytokine, Endothelium, Clinical outcome, serum, myocardial injury, Viral, myocarditis, Hypoxemia, Patient, Myocardial infarction, utility, mechanism, COVID-19 patients, Evidence, hyperinflammatory state, Injury, microangiopathy, Prognostic factor, hypercoagulable, evidence of, Myocardium, mechanism of injury, viral invasion, prothrombotic state, while, pathological mechanism, significantly, include, subsequent, elevated, suggested, cTn, 【제목키워드】 cardiovascular disease,