Aim: To elucidate the transcriptional characteristics of COVID-19. Materials & methods: We utilized an integrative approach to comprehensively analyze the transcriptional features of both COVID-19 patients and SARS-CoV-2 infected cells. Results: Widespread infiltration of immune cells was observed. We identified 233 genes that were codifferentially expressed in both bronchoalveolar lavage fluid and lung samples of COVID-19 patients. Functional analysis suggested upregulated genes were related to immune response such as neutrophil activation and antivirus response, while downregulated genes were associated with cell adhesion. Finally, we identified LCN2 , STAT1 and UBE2L6 as core genes during SARS-CoV-2 infection. Conclusion: The identification of core genes involved in COVID-19 can provide us with more insights into the molecular features of COVID-19.
【저자키워드】 COVID-19, SARS-CoV-2, Stat1, transcriptional features, Lcn2, 【초록키워드】 immune response, SARS-COV-2 infection, neutrophil, lung, Characteristics, Bronchoalveolar lavage fluid, immune cells, Stat1, COVID-19 patients, Bronchoalveolar lavage, infiltration, Analysis, Immune cell, COVID-19 patient, neutrophil activation, core genes, material, molecular features, SARS-CoV-2 infected cells, upregulated genes, Lcn2, upregulated gene, UBE2L6, approach, feature, Cell, transcriptional, involved, expressed, suggested, core gene, downregulated gene, molecular feature, 【제목키워드】 Integrative analysis, feature, transcriptional, involved,