Multiple variants of SARS-CoV-2 have emerged and are now prevalent at the global level. Currently designated variants of concern (VOCs) are B.1.1.7, B1.351, P.1, B.1.617.2 variants and B.1.1.529. Possible options for VOC are urgently required as they carry mutations in the virus spike protein that allow them to spread more easily and cause more serious illness. The primary targets for most therapeutic methods against SARS-CoV-2 are the S (Spike) protein and RBD (Receptor-Binding Domain), which alter the binding to ACE2 (Angiotensin-Converting Enzyme 2). The most popular of these strategies involves the use of drug development targeting the RBD and the NTD (N-terminal domain) of the spike protein and multiple epitopes of the S protein. Various types of mutations have been observed in the RBDs of B.1.1.7, B1.351, P. and B.1.620. The incidence of RBD mutations increases the binding affinity to the ACE2 receptor. The high binding affinity of RBD and ACE2 has provided a structural basis for future evaluation of antibodies and drug development. Here we discuss the variants of SARS-CoV-2 and recent updates on the clinical evaluation of antibody-based treatment options. Presently, most of the antibody-based treatments have been effective in patients with SARS-CoV-2. However, there are still significant challenges in verifying independence, and the need for further clinical evaluation.
【저자키워드】 Treatment, SARS-CoV-2, Efficacy, antibody, neutralization, variant, 【초록키워드】 ACE2, Mutation, Drug development, S protein, spike, antibody, VoC, variants of concern, B.1.617.2, ACE2 receptor, variants, binding affinity, Spike protein, Spread, Protein, Epitopes, Receptor-binding domain, clinical evaluation, B.1.1.7, RBD, P.1, therapeutic, VOCs, target, NTD, B.1.1.529, incidence, binding, N-terminal domain, RBD mutations, Angiotensin-converting enzyme, angiotensin, RBDs, Independence, Multiple, B1.351, virus spike protein, variants of SARS-CoV-2, multiple epitopes, Alter, effective, RBD mutation, prevalent, required, provided, increase, the spike protein, the RBD, the S protein, the binding affinity, multiple epitope, patients with SARS-CoV-2, 【제목키워드】 clinical, recent,